Slipping past P glycoprotein

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Slipping Past the Cordon: A Systematization of Internet Censorship Resistance

The Internet censorship conflict is like a game of cat-and-mouse, in which the censor discovers and acts on distinguishers that set the usage of censorship resistance systems (CRSs) apart from other Internet usage, and the CRSs’ attempts to remove and mitigate these distinguishers. Our systematization is based on a simple and intuitive model of the distinguisher-leveraging censorship apparatus,...

متن کامل

p-glycoprotein quantitation in acute leukemia

multi drug resistance(mdr) is a major problem in the treatment of cancer and hemalological malignancies. this resistance is multi factorial and is the result of decreased intra cellular drug accumulation. this is partly due to the presence of a 170kd intra membranous protein termed p-glycoprotein(p-gp) that is an energy-dependent efflux pump which has increased expression on drug-resistance cel...

متن کامل

P-glycoprotein and tumor progression.

Development of resistance to chemotherapy is a hallmark of many advanced human cancers. The molecular basis of clinical resistance is not well understood. Over the past 15 years, a number of different molecular mechanisms of resistance to anticancer drugs have been identified in many cell lines. One mechanism involves the increased expression of the plasma membrane P-glycoprotein (Pgp), which i...

متن کامل

The P-glycoprotein multidrug transporter.

Pgp (P-glycoprotein) (ABCB1) is an ATP-powered efflux pump which can transport hundreds of structurally unrelated hydrophobic amphipathic compounds, including therapeutic drugs, peptides and lipid-like compounds. This 170 kDa polypeptide plays a crucial physiological role in protecting tissues from toxic xenobiotics and endogenous metabolites, and also affects the uptake and distribution of man...

متن کامل

P-Glycoprotein in clinical cardiology.

Ever since Juliano and Ling first described P-glycoprotein (P-gp) in 1975, it has become an important focus of research. P-gp is a member of the ATP-binding cassette (ABC) superfamily of proteins that is highly conserved in distantly related species (from simple eukaryotes to vertebrates). These similarities across species suggest that P-gp plays an important role in physiological processes in ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Science-Business eXchange

سال: 2012

ISSN: 1945-3477

DOI: 10.1038/scibx.2012.1019